intolerance


Medication Intolerances 3 [Show Notes]

Tidbits about Headaches

A headache is an ambiguous side effect because there are so many different things that can cause headaches.  Hormones are a big culprit of this.  Blood pressure medications can too.

For someone with chronic high blood pressure, the higher pressure becomes the body’s new “normal”.  Once medication starts to bring it down, even though the pressures are within a normal range, the body will experience symptoms of low blood pressure.

2 lies people tell about allergies

  1. No allergies – so then they take something they are allergic to and have an emergency
  2. Allergic to “everything” – because they experienced mild or moderate side effects.  Or in the case of pain pill seekers, they’re “allergic” to the weak pain meds to get the doctor to prescribe stronger ones.

Stimulants

Irritability, nervousness, jitteriness, or moodiness can be a side effect of amphetamines (used for ADD) or cold medicines (i.e. pseudoephedrine).

A factoid about ADD/ADHD:  the focus and attention area of the brain are underactive, so a stimulant helps it be more active so improve focus.

The biggest complaint people have from any stimulant is the inability to sleep at night.  Just need to make sure it’s taken early enough in the day so it wears off in time for bed.

Bones and Joints

In this case, we rarely want you to keep taking the medication if these side effects happen.  For example, cholesterol medications (i.e. statins, and fibrates) and quinolone antibiotics (Levaquin, Cipro, Avelox).  The quinolones have a rare but serious side effect of tendon rupture; it is painful and permanent.

Tendons: the connective tissue that anchors muscles to the bones.

Osteoporosis medications can lead to bone pain – since their job is to cause changes in the way the bones are built and rebuilt, it’s not uncommon to feel something.  But usually temporary.

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Medication Intolerances 2 [Show Notes]

3 drug intolerances that involve the skin

  1. Itching and rash – even though they are a big sign of allergies, they also can be typical side effects of medications
    • Narcotics – in hospitals, they give diphenhydramine (Benadryl) to calm an itching side effect
    • Sulfa antibiotics and tetracyclines – sun hypersensitivity.  Not a sunburn, though.  May require pain reliever to get comfortable.
  2. Flushing – redness and hotness of the skin
    • Niacin – used for cholesterol reduction.  Flushing is reduced by taking 81 mg of aspirin 30 minutes before taking niacin
    • Hormones – natural or in medication (birth control or hormone replacement).  Can be reduced or eased by taking before bed or taking with food
    • IV contrast – as the medication spreads through the body.
  3. Dryness – especially of skin surfaces that require moisture (i.e. mucous membranes)
    • Antihistamines and cold medications – dry eyes, dry nose
    • Overactive bladder medications – dry eyes, dry mouth, constipation
    • IBS meds that control diarrhea – constipation

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Medication Intolerances 1 [Show Notes]

Allergy vs Intolerance

Medication allergies, especially the dangerous, life-threatening kind, affect your entire body, multiple organ systems, and put you at serious risk of death.  They also require immediate medical attention.

Symptoms include:

  • Serious swelling
  • Not being able to breathe or swallow
  • Significant speeding or slowing of your heart rate or breathing
  • Blood leaking out of blood vessels into other regions of your body

Intolerances are usually related to regular side effects of the medications, but are so bad that you can’t tolerate it.  At no time should you be asked to keep taking something that makes you feel worse than death.  And in most cases, avoid it at all costs.  Other times, the discomfort can be short-lived or fixed by altering how the medication is used.

My main point is: intolerances to medication side effects are not true allergies (even though a lot of people will group them together when giving a medical history to a doctor or pharmacy).

Nausea

Nausea is a side effect of almost everything that you swallow.  It’s too vague and nondescript to be an allergy.  It is usually due to the increase in acid production by the stomach when it is trying to break down and dissolve the medication.

Nausea can be caused by:

  • Pain medications (narcotics)
  • Antibiotics
  • Any large, powdery elephant-sized tablet
  • Multivitamins

Nausea is a potential side effect of almost everything that you swallow.  It’s too vague and nondescript to be an allergy.  It is usually due to the increase in acid production by the stomach when it is trying to break down and dissolve the medication.

The main way to avoid nausea is to take the medication with food – and in some cases, a decent amount of food.

Some widespread advice is to take medications with milk because milk is a base to counteract the stomach acid.  Unfortunately, the calcium in milk and cause certain antibiotics to not work.  Also, some medications require acid to be activated, so making the stomach less acidic, reduces their effectiveness.

A Positive Side of Nausea?

Certain injectable medications for Type 2 Diabetes have a main side effect of nausea or indigestion.  With these medications, the patients are encouraged to keep taking them.  The logic behind this is that in most cases, someone with Type 2 Diabetes will be overweight.  And they may have been resistant to the lifestyle changes (i.e. diet and exercise) that would help improve their weight, thus also improving the diabetes outcomes.  So, if they take a medication that causes nausea thus reducing their appetite, it helps them limit their food intake, and the final results will most likely be weight loss.  This is really what the manufacturers think!

Diarrhea

Diarrhea can be caused by:

  • Antibiotics: They kill the bad bacteria that are making you sick, but also your good bacteria.
    • Take probiotics or eat live culture yogurt (the more diverse the better)
  • Certain cholesterol medications: Particularly, the ones that help trap up the fat in your intestines so it’s not absorbed and add it to your waste that is about to exit.  Fat is an oil.  Oil is slippery.  Poo that is slippery…you get the idea.
    • The less fat you eat, the less slippery things will be.
  • Metformin: It causes diarrhea in the beginning while the body is adjusting to it.  Diarrhea lasting a month sounds like forever, but is really not compared to the amount of time (aka the rest of your life) that someone may have to take this medication for Type 2 Diabetes.
    • The best way to control this is to start this medication low and slow.

The best way to counteract long-term diarrhea issues from medications is to use bulking fiber.  They help absorb extra water and add solid substance to stool so it’s firmer.

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